Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.

Yang, Shengyong; Deng, Peng; Zhu, Zhaowei; Zhu, Jianzhong; Wang, Guoliang; Zhang, Liyong; Chen, Alex F; Wang, Tony; Sarkar, Saumendra N; Billiar, Timothy R; Wang, Qingde

Yang, Shengyong; Deng, Peng; Zhu, Zhaowei; Zhu, Jianzhong; Wang, Guoliang; Zhang, Liyong; Chen, Alex F; Wang, Tony; Sarkar, Saumendra N; Billiar, Timothy R; Wang, Qingde.

Afiliação

Yang S; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
Deng P; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; Department of Pathophysiology, Southern Medical University, Guangzhou, China 510515;
Zhu Z; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
Zhu J; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and.
Wang G; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
Zhang L; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
Chen AF; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
Wang T; Department of Immunology and Infectious Disease, SRI Biosciences, Lexington Park, MD 20653.
Sarkar SN; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and.
Billiar TR; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; wangq2@upmc.edu billiartr@upmc.edu.
Wang Q; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; wangq2@upmc.edu billiartr@upmc.edu.

J Immunol ; 193(7): 3436-45, 2014 Oct 01.

Article em En | MEDLINE | ID: mdl-25172485

Assuntos

Adenosina Desaminase/imunologia; RNA Helicases DEAD-box/imunologia; RNA Helicases DEAD-box/metabolismo; Interferon Tipo I/imunologia; RNA Viral/imunologia; Vírus Sendai/imunologia; Adenosina Desaminase/genética; Animais; Doenças Autoimunes do Sistema Nervoso/genética; Doenças Autoimunes do Sistema Nervoso/imunologia; Doenças Autoimunes do Sistema Nervoso/patologia; Proteína DEAD-box 58; RNA Helicases DEAD-box/genética; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Interferon Tipo I/genética; Camundongos; Camundongos Knockout; Malformações do Sistema Nervoso/genética; Malformações do Sistema Nervoso/imunologia; Malformações do Sistema Nervoso/patologia; RNA Viral/genética; Proteínas de Ligação a RNA; Receptores Imunológicos; Vírus Sendai/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Viral / Interferon Tipo I / Adenosina Desaminase / Vírus Sendai / RNA Helicases DEAD-box Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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