Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3.
Org Biomol Chem
; 12(41): 8180-95, 2014 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-25183239
ABSTRACT
We report here the syntheses of mono- to tetravalent glycoclusters containing 1-methylene-C-ß-lactose. The 1-methylene-C-ß-lactose moiety has been synthesized from octa-acetyl-ß-lactose using the key carbonyl insertion reaction and linked to a series of alkynlated scaffolds via CuAAC reaction to afford mono- to tetravalent glycoclusters. The binding affinities of the final products to galectin-3 were found in the range of 10-100 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoconjugados
/
Galectina 3
/
Lactose
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article