New pROSpects for PTP1B: micro-managing oncogene-induced senescence.

Banh, Robert S; Xu, Yang; Neel, Benjamin G

Banh, Robert S; Xu, Yang; Neel, Benjamin G.

Afiliação

Banh RS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
Xu Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
Neel BG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address: bneel@uhnresearch.ca.

Mol Cell ; 55(5): 651-3, 2014 Sep 04.

Article em En | MEDLINE | ID: mdl-25192363

ABSTRACT

ABSTRACT

Oncogene-induced senescence (OIS) provides an important, but incompletely understood, barrier to tumorigenesis. In this issue, Yang et al. (2014) surprisingly report that inactivation of PTP1B by reactive oxygen species is essential for OIS, via effects on AGO2 and microRNA maturation.

Assuntos

Proteínas Argonautas/metabolismo; Inativação Gênica; Proteína Tirosina Fosfatase não Receptora Tipo 1/fisiologia; Tirosina/metabolismo; Proteínas ras/fisiologia; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / Proteínas ras / Inativação Gênica / Proteína Tirosina Fosfatase não Receptora Tipo 1 / Proteínas Argonautas Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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