Markers of a recent bocavirus infection in children with Kawasaki disease: "a year prospective study".
Pathol Biol (Paris)
; 62(6): 365-8, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25193448
ABSTRACT
BACKGROUND:
Retrospective studies and case-reports have suggested the possible role of various viruses in the pathogenesis of the Kawasaki disease.OBJECTIVES:
To determine prospectively the incidence of Kawasaki diseases associated with a recent bocavirus infection in the course of a year. STUDYDESIGN:
Thirty-two children with Kawasaki disease were enrolled in a 13 months prospective study to assess the frequency of human bocavirus type 1 infections. Seasonal shedding of virus, markers of recent infection such as viraemia, viral load, and serum interferon alpha were analyzed.RESULTS:
Three of 32 (9%) children had HBoV-DNA in the serum suggesting a recent infection. HBoV-DNA was detected in naso-pharyngeal aspiration of 7/32 (21.8%) children with Kawasaki Disease and six of them (18%) had an increased viral load. No common respiratory viruses were isolated from the 32 patients with the exception of one adenovirus. The seven bocaviruses were identified during the winter-spring season. In addition, 4 of 7 of Kawasaki disease patients shedding bocavirus had detectable interferon alpha in the blood, indicating a possible active or recent viral infection.CONCLUSIONS:
This study shows that a recent bocavirus infection is concomitant with the onset of some cases of Kawasaki disease. Bocavirus may be a cofactor in the pathogenesis of this disease as previously reported for other infectious agents.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Infecções por Parvoviridae
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Bocavirus Humano
/
Síndrome de Linfonodos Mucocutâneos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
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Child, preschool
/
Female
/
Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article