Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.

Lawrenson, Kate; Mhawech-Fauceglia, Paulette; Worthington, Jenny; Spindler, Tassja J; O'Brien, Darragh; Lee, Janet M; Spain, Georgia; Sharifian, Maryam; Wang, Guisong; Darcy, Kathleen M; Pejovic, Tanja; Sowter, Heidi; Timms, John F; Gayther, Simon A

Lawrenson, Kate; Mhawech-Fauceglia, Paulette; Worthington, Jenny; Spindler, Tassja J; O'Brien, Darragh; Lee, Janet M; Spain, Georgia; Sharifian, Maryam; Wang, Guisong; Darcy, Kathleen M; Pejovic, Tanja; Sowter, Heidi; Timms, John F; Gayther, Simon A.

Afiliação

Lawrenson K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Mhawech-Fauceglia P; Departments of Medicine and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Worthington J; Cancer Proteomics Group, Institute for Women's Health, University College London, London, United Kingdom.
Spindler TJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
O'Brien D; Cancer Proteomics Group, Institute for Women's Health, University College London, London, United Kingdom.
Lee JM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Spain G; Cancer Proteomics Group, Institute for Women's Health, University College London, London, United Kingdom.
Sharifian M; Departments of Medicine and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Wang G; Women's Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale, VA.
Darcy KM; Women's Health Integrated Research Center at Inova Health System, Gynecologic Cancer Center of Excellence, Annandale, VA.
Pejovic T; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR.
Sowter H; Biological and Forensic Science Department, University of Derby, Derby, United Kingdom.
Timms JF; Cancer Proteomics Group, Institute for Women's Health, University College London, London, United Kingdom.
Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Int J Cancer ; 137(8): 1806-17, 2015 Oct 15.

Article em En | MEDLINE | ID: mdl-25204737

Assuntos

Biomarcadores Tumorais/metabolismo; Neoplasias Epiteliais e Glandulares/genética; Neoplasias Epiteliais e Glandulares/metabolismo; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/metabolismo; Proteômica/métodos; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Proto-Oncogênicas/genética; Proteínas ras/genética; Adipocinas/metabolismo; Proteínas Reguladoras de Apoptose/metabolismo; Carcinoma Epitelial do Ovário; Linhagem Celular Tumoral; Proteína 1 Semelhante à Quitinase-3; Ácido Graxo Sintase Tipo I/metabolismo; Feminino; Cromatografia Gasosa-Espectrometria de Massas/métodos; Regulação Neoplásica da Expressão Gênica; Humanos; Técnicas In Vitro; Lectinas/metabolismo; Modelos Genéticos; Neoplasias Epiteliais e Glandulares/patologia; Proteínas Nucleares/metabolismo; Neoplasias Ovarianas/patologia; Prognóstico; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Proto-Oncogênicas c-myc/metabolismo; Proteínas Proto-Oncogênicas p21(ras); Proteínas ras/metabolismo

Palavras-chave

3D models; MAPK; SILAC; biomarkers; early detection; ovarian cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Proteínas Proto-Oncogênicas c-myc / Proteínas Proto-Oncogênicas / Neoplasias Epiteliais e Glandulares / Proteínas ras / Proteômica Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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