Analysis of long-term stored plasma samples for investigation into the pathophysiology of vibration-induced white finger: preliminary results.
Ind Health
; 52(6): 548-51, 2014.
Article
em En
| MEDLINE
| ID: mdl-25224335
ABSTRACT
Blood samples were collected 25â
yr ago from hand-arm vibration syndrome patients with vibration-induced white finge/VWF (VWF+ group) and without it (VWF- group), and healthy controls (n=12 in each group), and stored at -80 °C. The subjects provided venous blood twice at baseline, and after cold exposure at 7 °C for 25â
min. Blood specimens were analyzed for plasma endothelin-1 (ET-1) by an enzyme-linked immunosorbent assay. Baseline concentration of plasma ET-1 was found to be significantly larger in the VWF- group than the control group, whereas no such difference was observed for the VWF+ group. However, the %change was larger in the VWF+ group (107.73 ± 30.49%) than the other two groups, and more subjects in the VWF+ group showed the maximum increase in ET-1 than the other two groups. In conclusion, ET-1 appears to have a role in the pathophysiology of VWF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coleta de Amostras Sanguíneas
/
Endotelina-1
/
Síndrome da Vibração do Segmento Mão-Braço
Tipo de estudo:
Observational_studies
Limite:
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article