Anti-HIV-1 activity of phlorotannin derivative 8,4â´-dieckol from Korean brown alga Ecklonia cava.
Biosci Biotechnol Biochem
; 78(7): 1151-8, 2014.
Article
em En
| MEDLINE
| ID: mdl-25229850
ABSTRACT
8,4â´-dieckol is a natural product which has been isolated from brown alga, Ecklonia cava. This polyphenolic compound is a phlorotannin derivative with a broad range of bioactivities. Its inhibitory activity on human immunodeficiency virus type-1 (HIV-1) was tested and the results indicated that 8,4â´-dieckol inhibited HIV-1 induced syncytia formation, lytic effects, and viral p24 antigen production at noncytotoxic concentrations. Furthermore, it was found that 8,4â´-dieckol selectively inhibited the activity of HIV-1 reverse trancriptase (RT) enzyme with 91% inhibition ratio at the concentration of 50 µM. HIV-1 entry was also inhibited by 8,4â´-dieckol. According to data from this study, 8,4â´-dieckol is an effective compound against HIV-1 with high potential for further studies. These results suggest that it might be used as a drug candidate for the development of new generation therapeutic agents, although further studies on the mechanism of inhibition should be addressed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taninos
/
Benzofuranos
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HIV-1
/
Fármacos Anti-HIV
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Phaeophyceae
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article