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Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
Springelkamp, Henriët; Höhn, René; Mishra, Aniket; Hysi, Pirro G; Khor, Chiea-Chuen; Loomis, Stephanie J; Bailey, Jessica N Cooke; Gibson, Jane; Thorleifsson, Gudmar; Janssen, Sarah F; Luo, Xiaoyan; Ramdas, Wishal D; Vithana, Eranga; Nongpiur, Monisha E; Montgomery, Grant W; Xu, Liang; Mountain, Jenny E; Gharahkhani, Puya; Lu, Yi; Amin, Najaf; Karssen, Lennart C; Sim, Kar-Seng; van Leeuwen, Elisabeth M; Iglesias, Adriana I; Verhoeven, Virginie J M; Hauser, Michael A; Loon, Seng-Chee; Despriet, Dominiek D G; Nag, Abhishek; Venturini, Cristina; Sanfilippo, Paul G; Schillert, Arne; Kang, Jae H; Landers, John; Jonasson, Fridbert; Cree, Angela J; van Koolwijk, Leonieke M E; Rivadeneira, Fernando; Souzeau, Emmanuelle; Jonsson, Vesteinn; Menon, Geeta; Weinreb, Robert N; de Jong, Paulus T V M; Oostra, Ben A; Uitterlinden, André G; Hofman, Albert; Ennis, Sarah; Thorsteinsdottir, Unnur; Burdon, Kathryn P; Spector, Timothy D.
Afiliação
  • Springelkamp H; 1] Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Höhn R; Department of Ophthalmology, University Medical Center Mainz, Mainz 55131, Germany.
  • Mishra A; Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland 4006, Australia.
  • Hysi PG; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
  • Khor CC; 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119077, Singapore [2] Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
  • Loomis SJ; Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
  • Bailey JN; 1] Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA [2] Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
  • Gibson J; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton SO17 1BJ, UK.
  • Thorleifsson G; deCODE/Amgen, Reykjavik 101, Iceland.
  • Janssen SF; Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam 1105 BA, the Netherlands.
  • Luo X; Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina 27710, USA.
  • Ramdas WD; Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Vithana E; 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119077, Singapore [2] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore [3] Duke-National University of Singapore, Graduate Medical School, Sin
  • Nongpiur ME; 1] Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119077, Singapore [2] Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
  • Montgomery GW; Department of Genetics and Computational Biology, Molecular Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland 4006, Australia.
  • Xu L; 1] Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2] Beijing Ophthalmology and Visual Science Key Lab, Beijing 100730, China.
  • Mountain JE; Telethon Institute for Child Health Research, Subiaco, Western Australia 6008, Australia.
  • Gharahkhani P; Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland 4006, Australia.
  • Lu Y; Department of Genetics and Computational Biology, Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland 4006, Australia.
  • Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Karssen LC; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Sim KS; Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
  • van Leeuwen EM; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Iglesias AI; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Verhoeven VJ; 1] Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Hauser MA; Departments of Medicine and Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA.
  • Loon SC; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119077, Singapore.
  • Despriet DD; Department of Ophthalmology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Nag A; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
  • Venturini C; 1] Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK [2] UCL Institute of Ophthalmology, London EC1V 9EL, UK.
  • Sanfilippo PG; Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
  • Schillert A; Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck 23562, Germany.
  • Kang JH; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
  • Landers J; Department of Ophthalmology, Flinders University, Adelaide, South Australia 5042, Australia.
  • Jonasson F; 1] Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland [2] Department of Ophthalmology, Landspitali National University Hospital, Reykjavik 101, Iceland.
  • Cree AJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
  • van Koolwijk LM; Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Rivadeneira F; 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [3] Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague 2593 CE, The Netherlands
  • Souzeau E; Department of Ophthalmology, Flinders University, Adelaide, South Australia 5042, Australia.
  • Jonsson V; Department of Ophthalmology, Landspitali National University Hospital, Reykjavik 101, Iceland.
  • Menon G; Department of Ophthalmology, Frimley Park Hospital NHS Foundation Trust, Frimley GU16 7UJ, UK.
  • Weinreb RN; Department of Ophthalmology and Hamilton Glaucoma Center, University of California, San Diego, California 92093, USA.
  • de Jong PT; 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Department of Retinal Signal Processing, Netherlands Institute for Neuroscience, Amsterdam 1105 BA, The Netherlands [3] Department of Ophthalmology, Academic Medical Center, Amsterdam 1105 AZ, The Netherlan
  • Oostra BA; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.
  • Uitterlinden AG; 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [3] Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague 2593 CE, The Netherlands
  • Hofman A; 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague 2593 CE, The Netherlands.
  • Ennis S; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
  • Thorsteinsdottir U; 1] deCODE/Amgen, Reykjavik 101, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
  • Burdon KP; Department of Ophthalmology, Flinders University, Adelaide, South Australia 5042, Australia.
  • Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London WC2R 2LS, UK.
Nat Commun ; 5: 4883, 2014 Sep 22.
Article em En | MEDLINE | ID: mdl-25241763
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glaucoma / Estudo de Associação Genômica Ampla Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glaucoma / Estudo de Associação Genômica Ampla Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article