Chemical dynamic kinetic resolution and S/Râ
interconversion of unprotected α-amino acids.
Angew Chem Int Ed Engl
; 53(45): 12214-7, 2014 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-25244328
Reported herein is the first purely chemical method for the dynamic kinetic resolution (DKR) of unprotected racemic α-amino acids (α-AAs), a method which can rival the economic efficiency of the enzymatic reactions. The DKR reaction principle can be readily applied for S/Râ
interconversions of α-AAs, the methodological versatility of which is unmatched by biocatalytic approaches. The presented process features a virtually complete stereochemical outcome, fully recyclable source of chirality, and operationally simple and convenient reaction conditions, thus allowing its ready scalability. A quite unique and novel mode of the thermodynamic control over the stereochemical outcome, including an exciting interplay between axial, helical, and central elements of chirality is proposed.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoácidos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article