Bmi-1 regulates the migration and invasion of glioma cells through p16.
Cell Biol Int
; 39(3): 283-90, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25262972
ABSTRACT
Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Inibidor p16 de Quinase Dependente de Ciclina
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Complexo Repressor Polycomb 1
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Glioma
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article