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Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.
Zoraghi, Roya; Campbell, Sara; Kim, Catrina; Dullaghan, Edie M; Blair, Lachlan M; Gillard, Rachel M; Reiner, Neil E; Sperry, Jonathan.
Afiliação
  • Zoraghi R; Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver V5Z 3J5, Canada.
  • Campbell S; Centre for Drug Research and Development (CDRD), Vancouver, British Columbia, Canada.
  • Kim C; Centre for Drug Research and Development (CDRD), Vancouver, British Columbia, Canada.
  • Dullaghan EM; Centre for Drug Research and Development (CDRD), Vancouver, British Columbia, Canada.
  • Blair LM; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
  • Gillard RM; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
  • Reiner NE; Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver V5Z 3J5, Canada; Department of Microbiology and Immunology, University of British Columbia, Vancouver V5Z 3J5, Canada.
  • Sperry J; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Bioorg Med Chem Lett ; 24(21): 5059-62, 2014 Nov 01.
Article em En | MEDLINE | ID: mdl-25266785
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Inibidores Enzimáticos / Etano / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Inibidores Enzimáticos / Etano / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article