CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.

Jia, Xin-Ming; Tang, Bing; Zhu, Le-Le; Liu, Yan-Hui; Zhao, Xue-Qiang; Gorjestani, Sara; Hsu, Yen-Michael S; Yang, Long; Guan, Jian-Hong; Xu, Guo-Tong; Lin, Xin

Jia, Xin-Ming; Tang, Bing; Zhu, Le-Le; Liu, Yan-Hui; Zhao, Xue-Qiang; Gorjestani, Sara; Hsu, Yen-Michael S; Yang, Long; Guan, Jian-Hong; Xu, Guo-Tong; Lin, Xin.

Afiliação

Jia XM; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China jiaxm@tongji.edu.cn xllin@mdanderson.org.
Tang B; Department of Burns, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Zhu LL; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China.
Liu YH; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China.
Zhao XQ; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Gorjestani S; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Hsu YM; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Yang L; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China.
Guan JH; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China.
Xu GT; Research Center for Translational Medicine, Shanghai East Hospital, and Department of Immunology, Tongji University School of Medicine, Shanghai 200120, China.
Lin X; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 jiaxm@tongji.edu.cn xllin@mdanderson.org.

J Exp Med ; 211(11): 2307-21, 2014 Oct 20.

Article em En | MEDLINE | ID: mdl-25267792

Assuntos

Proteínas Adaptadoras de Sinalização CARD/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Fungos/imunologia; Lectinas Tipo C/metabolismo; Micoses/imunologia; Micoses/metabolismo; Proteínas ras/metabolismo; ras-GRF1/metabolismo; Animais; Proteínas Adaptadoras de Sinalização CARD/genética; Candida albicans/efeitos dos fármacos; Candida albicans/genética; Candida albicans/imunologia; Candidíase/genética; Candidíase/imunologia; Candidíase/metabolismo; Candidíase/mortalidade; Ativação Enzimática/efeitos dos fármacos; Feminino; Fungos/efeitos dos fármacos; Fungos/genética; Humanos; Imunidade Inata; Lectinas Tipo C/genética; Camundongos; Camundongos Knockout; Complexos Multiproteicos/metabolismo; Micoses/genética; Micoses/mortalidade; NF-kappa B/metabolismo; Ligação Proteica; Transdução de Sinais; beta-Glucanas/farmacologia; Proteínas ras/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas ras / Ras-GRF1 / Lectinas Tipo C / MAP Quinases Reguladas por Sinal Extracelular / Proteínas Adaptadoras de Sinalização CARD / Fungos / Micoses Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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