Interleukin-31 is associated with uremic pruritus in patients receiving hemodialysis.
J Am Acad Dermatol
; 71(6): 1151-1159.e1, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25270263
ABSTRACT
BACKGROUND:
Interleukin (IL)-31 induces severe pruritus and dermatitis in transgenic mice, and is associated with many itching skin diseases.OBJECTIVE:
We sought to investigate the association of serum IL-31 levels with uremic pruritus in patients undergoing hemodialysis.METHODS:
Patients receiving maintenance hemodialysis in a referral medical center were recruited. Serum IL-31 levels were determined by the enzyme-linked immunosorbent assay methodology. The various characteristics of pruritus were assessed using an interview questionnaire.RESULTS:
Among the 178 study participants, 34.8% had uremic pruritus. The patients with pruritus had higher serum IL-31 levels than those without pruritus symptoms (median 8.68 [first quartile 0.43, third quartile 35.04] vs 4.91 [0, 15.78], P = .04). A multivariate linear regression analysis showed that higher serum levels of IL-31, high-sensitivity C-reactive protein, and alanine transaminase, and a lower dialysis dose assessed by Kt/V, were independent predictors for higher pruritus intensity. The generalized additive model also showed a positive exposure-response relationship between serum levels of IL-31 and visual analog scale scores of pruritus intensity.LIMITATIONS:
The cause-effect relationship between IL-31 and uremic pruritus could not be assessed by the cross-sectional study design.CONCLUSION:
IL-31 may play an important role in the pathophysiology of uremic pruritus.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prurido
/
Uremia
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Diálise Renal
/
Interleucinas
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Falência Renal Crônica
Tipo de estudo:
Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article