[Preparation and pharmacokinetic evaluation of long-acting injectable oily suspensions for ophiopogonis radix polysaccharide MDG-1].
Zhongguo Zhong Yao Za Zhi
; 39(13): 2489-94, 2014 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-25276969
ABSTRACT
OBJECTIVE:
To evaluate in vivo pharmacokinetics of Ophiopogonis Radix polysaccharide MDG-1 oily suspension injection prepared with different prescriptions in rats, and explore the feasibility of the long-acting drug delivery of MDG-1 Injection by using the oily suspension drug release system.METHOD:
MDG-1 microparticles were prepared by the anti-solvent precipitation method. Their size and size distribution were characterized. Castor oil with a high viscosity or aluminum stearate were added into soybean oil with a low viscosity, in order to prepare oily media with different viscosities, detect their rheological properties and screen out superior prescriptions for in vivo evaluation.RESULT:
The average size of microparticles was 21.81 microm, and the span between them was 2.63. The in vivo evaluation was conducted for prescriptions of mixed oil (soybean oil/castor oil, 2 3) and soybean oils gelled by 2% and 4% aluminium stearate. Among them, the prescription of soybean gelled by 4% aluminium stearate could significantly reduce C(max) and prolong the apparent t1/2, with the MDG-1 release time of several days.CONCLUSION:
It is feasible to achieve the long-acting MDG-1 drug delivery by using oily media with a high viscosity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Óleos de Plantas
/
Medicamentos de Ervas Chinesas
/
Química Farmacêutica
/
Ophiopogon
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article