Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin &#945;3ß1-dependent.

Lerman, Yelena V; Lim, Kihong; Hyun, Young-Min; Falkner, Kathleen L; Yang, Hongmei; Pietropaoli, Anthony P; Sonnenberg, Arnoud; Sarangi, Pranita P; Kim, Minsoo

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3ß1-dependent.

Lerman, Yelena V; Lim, Kihong; Hyun, Young-Min; Falkner, Kathleen L; Yang, Hongmei; Pietropaoli, Anthony P; Sonnenberg, Arnoud; Sarangi, Pranita P; Kim, Minsoo.

Afiliação

Lerman YV; David H. Smith Center for Vaccine Biology and Immunology, Department of Pharmacology and Physiology.
Lim K; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.
Hyun YM; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.
Falkner KL; Pulmonary and Critical Care Medicine Division, and.
Yang H; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY; and.
Pietropaoli AP; Pulmonary and Critical Care Medicine Division, and.
Sonnenberg A; Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sarangi PP; David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.
Kim M; David H. Smith Center for Vaccine Biology and Immunology, Department of Pharmacology and Physiology, Department of Microbiology and Immunology.

Blood ; 124(24): 3515-23, 2014 Dec 04.

Article em En | MEDLINE | ID: mdl-25278585

Assuntos

Citocinas/imunologia; Integrina alfa3beta1/imunologia; Infiltração de Neutrófilos/imunologia; Neutrófilos/imunologia; Sepse/imunologia; Receptores Toll-Like/imunologia; Animais; Citocinas/genética; Modelos Animais de Doenças; Humanos; Integrina alfa3beta1/antagonistas & inibidores; Integrina alfa3beta1/genética; Masculino; Camundongos; Camundongos Knockout; Infiltração de Neutrófilos/efeitos dos fármacos; Infiltração de Neutrófilos/genética; Neutrófilos/patologia; Peptídeos/farmacologia; Sepse/induzido quimicamente; Sepse/tratamento farmacológico; Sepse/genética; Sepse/patologia; Receptores Toll-Like/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Sepse / Infiltração de Neutrófilos / Integrina alfa3beta1 / Receptores Toll-Like / Neutrófilos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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