Biological evaluation of halogenated thiazolo[3,2-a]pyrimidin-3-one carboxylic acid derivatives targeting the YycG histidine kinase.

Zhao, Dan; Chen, Chen; Liu, Huayong; Zheng, Likang; Tong, Yao; Qu, Di; Han, Shiqing

Zhao, Dan; Chen, Chen; Liu, Huayong; Zheng, Likang; Tong, Yao; Qu, Di; Han, Shiqing.

Afiliação

Zhao D; College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China.
Chen C; College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China.
Liu H; Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology and Institutes of Biomedical Sciences, Shanghai Medical School of Fudan University Box 228, Shanghai 200032, China.
Zheng L; College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China.
Tong Y; College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China.
Qu D; Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology and Institutes of Biomedical Sciences, Shanghai Medical School of Fudan University Box 228, Shanghai 200032, China. Electronic address: dqu@shmu.edu.cn.
Han S; College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China. Electronic address: hanshiqing@njut.edu.cn.

Eur J Med Chem ; 87: 500-7, 2014 Nov 24.

Article em En | MEDLINE | ID: mdl-25282671

Assuntos

Antibacterianos/farmacologia; Ácidos Carboxílicos/química; Halogênios/química; Proteínas Quinases/efeitos dos fármacos; Pirimidinas/farmacologia; Tiazóis/química; Antibacterianos/química; Biofilmes; Hemólise/efeitos dos fármacos; Histidina Quinase; Espectroscopia de Ressonância Magnética; Testes de Sensibilidade Microbiana; Pirimidinas/química; Espectrometria de Massas por Ionização por Electrospray; Espectrofotometria Infravermelho; Staphylococcus epidermidis/efeitos dos fármacos

Palavras-chave

Antibacterial activity; Antibiofilm activity; Halogenated thiazolo[3,2-a]pyrimidin-3-one; Staphylococcus aureus; Staphylococcus epidermidis; YycG histidine kinase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Pirimidinas / Tiazóis / Ácidos Carboxílicos / Halogênios / Antibacterianos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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