Efficacy of levamisole alone and in combination with mebendazole against Gongylonema pulchrum infection in rabbits.
J Vet Med Sci
; 77(1): 113-6, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25298240
ABSTRACT
Gongylonema pulchrum is an important parasite of captive primates. Twelve rabbits were infected with 30 third-stage larvae of G. pulchrum. At 4-7 months post-infection, animals were administered levamisole at a single dose of 12 mg/kg, levamisole at 8 mg/kg three times at 2-day intervals, levamisole at a single dose of 8 mg/kg after administration of mebendazole at 70 mg/kg for 3 days or 8 ml of distilled water for 3 days (control). Necropsy at 14 days after treatment revealed that single and multiple dosages of levamisole reduced nematode burdens by 68.4% and 89.5%, respectively. The combined regimen of mebendazole and levamisole exhibited high efficacy for treating G. pulchrum located widely within the upper digestive tract, with a reduction of 98.2%. These results suggest that this combined chemotherapy treatment may be effective against G. pulchrum infection, including buccal and lingual gongylonemiasis in primates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coelhos
/
Spiruroidea
/
Levamisol
/
Infecções por Spirurida
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Mebendazol
/
Antinematódeos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article