Sequential combination of mitomycin C plus bacillus Calmette-Guérin (BCG) is more effective but more toxic than BCG alone in patients with non-muscle-invasive bladder cancer in intermediate- and high-risk patients: final outcome of CUETO 93009, a randomized prospective trial.

Solsona, Eduardo; Madero, Rosario; Chantada, Venancio; Fernandez, Jesus M; Zabala, Juan A; Portillo, José A; Alonso, Jose M; Astobieta, Ander; Unda, Miguel; Martinez-Piñeiro, Luis; Rabadan, Mariano; Ojea, Antonio; Rodriguez-Molina, Jesus; Beardo, Pastora; Muntañola, Pedro; Gomez, Matias; Montesinos, Manuel; Martinez Piñeiro, Jose A

Solsona, Eduardo; Madero, Rosario; Chantada, Venancio; Fernandez, Jesus M; Zabala, Juan A; Portillo, José A; Alonso, Jose M; Astobieta, Ander; Unda, Miguel; Martinez-Piñeiro, Luis; Rabadan, Mariano; Ojea, Antonio; Rodriguez-Molina, Jesus; Beardo, Pastora; Muntañola, Pedro; Gomez, Matias; Montesinos, Manuel; Martinez Piñeiro, Jose A.

Afiliação

Solsona E; Department of Urology, Instituto Valenciano de Oncología, Valencia, Spain. Electronic address: solsona@pulso.com.
Madero R; Department of Statistics, Hospital La Paz, Madrid, Spain.
Chantada V; Department of Urology, Complejo Hospitalario Universitario a Coruña, La Coruña, Spain.
Fernandez JM; Department of Urology, Hospital Central de Asturias, Oviedo, Spain.
Zabala JA; Department of Urology, Hospital Cruces, Bilbao, Spain.
Portillo JA; Department of Urology, Hospital Universitario Marques de Valdecilla, Santander, Spain.
Alonso JM; Department of Urology, Hospital Universitario La Paz, Madrid, Spain.
Astobieta A; Department of Urology, Hospital de Galdakao, Bilbao, Spain.
Unda M; Department of Urology, Hospital de Basurto, Bilbao, Spain.
Martinez-Piñeiro L; Department of Urology, Hospital Princesa Sofia, Madrid, Spain.
Rabadan M; Department of Urology, Hospital de la Princesa, Madrid, Spain.
Ojea A; Department of Urology, Hospital Xeral, Vigo, Spain.
Rodriguez-Molina J; Department of Urology, Hospital Universitario de San Carlos, Madrid, Spain.
Beardo P; Department of Urology, Hospital General, Jerez de la Frontera, Spain.
Muntañola P; Department of Urology, Hospital Alvarez Buylla, Mieres, Spain.
Gomez M; Department of Urology, Hospital Negrin, Las Palmas de Gran Canaria, Spain.
Montesinos M; Department of Urology, Hospital Virgen del Camino, Pamplona, Spain.
Martinez Piñeiro JA; Department of Urology, Clínica La Luz, Madrid, Spain.

Eur Urol ; 67(3): 508-16, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25301758

Assuntos

Antibióticos Antineoplásicos/efeitos adversos; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Vacina BCG/efeitos adversos; Mitomicina/efeitos adversos; Neoplasias da Bexiga Urinária/tratamento farmacológico; Idoso; Quimioterapia Adjuvante; Cistectomia; Intervalo Livre de Doença; Feminino; Humanos; Análise de Intenção de Tratamento; Estimativa de Kaplan-Meier; Masculino; Pessoa de Meia-Idade; Invasividade Neoplásica; Recidiva Local de Neoplasia; Modelos de Riscos Proporcionais; Estudos Prospectivos; Espanha; Fatores de Tempo; Resultado do Tratamento; Neoplasias da Bexiga Urinária/patologia

Palavras-chave

BCG; Intermediate- to high-risk groups; MMC plus BCG; Randomized trial; Subgroup analysis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Vacina BCG / Protocolos de Quimioterapia Combinada Antineoplásica / Mitomicina / Antibióticos Antineoplásicos Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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