A rapid and divergent access to chiral azacyclic nucleoside analogues via highly enantioselective 1,3-dipolar cycloaddition of ß-nucleobase substituted acrylates.
Chem Commun (Camb)
; 50(94): 14809-12, 2014 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-25319349
ABSTRACT
A rapid and divergent access to chiral azacyclic nucleoside analogues has been established via highly exo-selective and enantioselective 1,3-dipolar cycloaddition of azomethine ylides with ß-nucleobase substituted acrylates. Using 1 mol% of a chiral copper complex, various chiral azacyclic nucleoside analogues were obtained in high yields, excellent exo-selectivities and enantioselectivities (98 to >99% ee).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Azo
/
Tiossemicarbazonas
/
Acrilatos
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article