Effects of flavonoid quercetin on survival of motor neuron gene expression.
Cell Biol Int
; 39(3): 350-4, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25319353
ABSTRACT
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that results in muscle weakness and atrophy. To attenuate disease severity, drug development studies have been applied mainly to target the Survival of Motor Neuron 2 (SMN2) gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2-inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. Gene expression studies showed that quercetin upregulates SMN2 mRNA up to fourfold, but not the SMN protein level.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quercetina
/
Regulação para Cima
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article