Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge.

Çuburu, Nicolas; Wang, Kening; Goodman, Kyle N; Pang, Yuk Ying; Thompson, Cynthia D; Lowy, Douglas R; Cohen, Jeffrey I; Schiller, John T

Çuburu, Nicolas; Wang, Kening; Goodman, Kyle N; Pang, Yuk Ying; Thompson, Cynthia D; Lowy, Douglas R; Cohen, Jeffrey I; Schiller, John T.

Afiliação

Çuburu N; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Wang K; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Goodman KN; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Pang YY; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Thompson CD; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Lowy DR; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Cohen JI; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Schiller JT; Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA schillej@dc37a.nci.nih.gov.

J Virol ; 89(1): 83-96, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25320297

Assuntos

Linfócitos T CD8-Positivos/imunologia; Herpes Genital/prevenção & controle; Vacinas contra Herpesvirus/imunologia; Papillomaviridae/genética; Proteínas do Envelope Viral/imunologia; Eliminação de Partículas Virais; Administração Intravaginal; Animais; Anticorpos Neutralizantes/sangue; Anticorpos Antivirais/sangue; Modelos Animais de Doenças; Feminino; Vetores Genéticos; Herpes Genital/imunologia; Herpes Genital/patologia; Herpesvirus Humano 2/genética; Herpesvirus Humano 2/imunologia; Vacinas contra Herpesvirus/administração & dosagem; Vacinas contra Herpesvirus/genética; Memória Imunológica; Injeções Intramusculares; Interferon gama/metabolismo; Camundongos Endogâmicos C57BL; Proteínas Recombinantes/genética; Proteínas Recombinantes/imunologia; Análise de Sobrevida; Fator de Necrose Tumoral alfa/metabolismo; Vacinação/métodos; Vacinas Sintéticas/administração & dosagem; Vacinas Sintéticas/genética; Vacinas Sintéticas/imunologia; Proteínas do Envelope Viral/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Herpes Genital / Proteínas do Envelope Viral / Eliminação de Partículas Virais / Linfócitos T CD8-Positivos / Vacinas contra Herpesvirus Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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