Mechanism and regulation of meiotic recombination initiation.
Cold Spring Harb Perspect Biol
; 7(1): a016634, 2014 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-25324213
ABSTRACT
Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Proteínas de Ciclo Celular
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Reparo do DNA
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Endodesoxirribonucleases
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Evolução Biológica
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Quebras de DNA de Cadeia Dupla
/
Meiose
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article