Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

Zhao, Qicheng; Duckworth, Carrie A; Wang, Weikun; Guo, Xiuli; Barrow, Hannah; Pritchard, D Mark; Rhodes, Jonathan M; Yu, Lu-Gang

Zhao, Qicheng; Duckworth, Carrie A; Wang, Weikun; Guo, Xiuli; Barrow, Hannah; Pritchard, D Mark; Rhodes, Jonathan M; Yu, Lu-Gang.

Afiliação

Zhao Q; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Duckworth CA; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Wang W; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Guo X; Department of Pharmacology, Shandong University, Shandong 250012, China.
Barrow H; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Pritchard DM; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Rhodes JM; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China.
Yu LG; Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, UK andDepartment of Pharmacology, Shandong University, Shandong 250012, China lgyu@liv.ac.uk.

Carcinogenesis ; 35(12): 2815-21, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25326505

Assuntos

Neoplasias do Colo/metabolismo; Neoplasias do Colo/secundário; Endotélio Vascular/efeitos dos fármacos; Galectina 3/metabolismo; Mucina-1/metabolismo; Aglutinina de Amendoim/farmacologia; Animais; Anoikis/efeitos dos fármacos; Apoptose; Western Blotting; Adesão Celular; Movimento Celular; Proliferação de Células; Neoplasias do Colo/tratamento farmacológico; Endotélio Vascular/metabolismo; Endotélio Vascular/patologia; Feminino; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Mucina-1/química; Mucina-1/genética; Metástase Neoplásica; Aglutinina de Amendoim/sangue; RNA Interferente Pequeno/genética; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Neoplasias do Colo / Mucina-1 / Aglutinina de Amendoim / Galectina 3 Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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