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PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
Ning, Xinghai; Seo, Wonewoo; Lee, Seungjun; Takemiya, Kiyoko; Rafi, Mohammad; Feng, Xuli; Weiss, Daiana; Wang, Xiaojian; Williams, Larry; Camp, Vernon M; Eugene, Malveaux; Taylor, W Robert; Goodman, Mark; Murthy, Niren.
Afiliação
  • Ning X; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
  • Seo W; Department of Radiology and Imaging Sciences, Emory University (USA).
  • Lee S; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
  • Takemiya K; Division of Cardiology, Department of Medicine, Emory University School of Medicine (USA).
  • Rafi M; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
  • Feng X; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
  • Weiss D; Division of Cardiology, Department of Medicine, Emory University School of Medicine (USA).
  • Wang X; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
  • Williams L; Department of Radiology and Imaging Sciences, Emory University (USA).
  • Camp VM; Department of Radiology and Imaging Sciences, Emory University (USA).
  • Eugene M; Department of Radiology and Imaging Sciences, Emory University (USA).
  • Taylor WR; Division of Cardiology, Department of Medicine and the Department of Biomedical Engineering, Emory University School of Medicine and the Atlanta VA Medical Center (USA).
  • Goodman M; Department of Radiology and Imaging Sciences, Emory University (USA).
  • Murthy N; Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
Angew Chem Int Ed Engl ; 53(51): 14096-14101, 2014 Dec 15.
Article em En | MEDLINE | ID: mdl-25330976
ABSTRACT
A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Radioisótopos de Flúor / Tomografia por Emissão de Pósitrons / Infecções por Escherichia coli Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Radioisótopos de Flúor / Tomografia por Emissão de Pósitrons / Infecções por Escherichia coli Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article