PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
Angew Chem Int Ed Engl
; 53(51): 14096-14101, 2014 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-25330976
ABSTRACT
A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria inâ
vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E.â
coli colony-forming units (CFUs), and can identify drug resistance in bacteria inâ
vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Radioisótopos de Flúor
/
Tomografia por Emissão de Pósitrons
/
Infecções por Escherichia coli
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article