[Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases].
Gan To Kagaku Ryoho
; 41(10): 1304-6, 2014 Oct.
Article
em Ja
| MEDLINE
| ID: mdl-25335725
ABSTRACT
We evaluated the significance of indoleamine 2,3-dioxygenase(IDO)activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine(Trp/Kyn)ratio. Trp and Kyn were measured by high-performance liquid chromatography(HPLC). The survival rate after recurrence was higher in the local recurrence group(n=11)than in the distant metastases group(n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Indolamina-Pirrol 2,3,-Dioxigenase
/
Recidiva Local de Neoplasia
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
Ja
Ano de publicação:
2014
Tipo de documento:
Article