A negatively charged residue stabilizes the tropoelastin N-terminal region for elastic fiber assembly.

Yeo, Giselle C; Baldock, Clair; Wise, Steven G; Weiss, Anthony S

Yeo, Giselle C; Baldock, Clair; Wise, Steven G; Weiss, Anthony S.

Afiliação

Yeo GC; From the School of Molecular Bioscience and Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.
Baldock C; the Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.
Wise SG; the Heart Research Institute, Sydney, New South Wales 2042, Australia, and the Sydney Medical School and.
Weiss AS; From the School of Molecular Bioscience and Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia, Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia tony.weiss@sydney.edu.au.

J Biol Chem ; 289(50): 34815-26, 2014 Dec 12.

Article em En | MEDLINE | ID: mdl-25342751

Assuntos

Ácido Aspártico; Elasticidade; Tropoelastina/química; Tropoelastina/metabolismo; Fibroblastos/metabolismo; Humanos; Modelos Moleculares; Mutagênese Sítio-Dirigida; Mutação; Estabilidade Proteica; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Pele/citologia; Tropoelastina/genética

Palavras-chave

Aspartate (Aspartic Acid); Domain 6; Elastic Fiber Assembly; Elastin; N-terminal Region; Protein Self-assembly; Small Angle X-ray Scattering; Tertiary Structure; Tropoelastin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tropoelastina / Ácido Aspártico / Elasticidade Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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