Relationship between SERPING1 rs2511989 polymorphism and age-related macular degeneration risk: a meta-analysis.
Mol Vis
; 20: 1434-42, 2014.
Article
em En
| MEDLINE
| ID: mdl-25352749
ABSTRACT
PURPOSE:
We conducted a meta-analysis aiming to evaluate the relationship between a common polymorphism (rs2511989 G>A) in the SERPING1 gene and the risk of age-related macular degeneration (AMD).METHODS:
The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1, 2013, without any language restrictions. A meta-analysis was conducted using STATA 12.0 software. We calculated a crude odds ratio (OR) with a 95% confidence interval (95% CI) to evaluate the relationships under five genetic models.RESULTS:
Seven case-control studies with a total of 7,159 patients with AMD and 5,797 healthy subjects met the inclusion criteria. The results of our meta-analysis showed that the SERPING1 rs2511989 polymorphism might be correlated with an increased risk of AMD (G allele versus A allele OR = 1.09, 95% CI = 1.03-1.15, p = 0.020; GG + GA versus AA OR = 1.14, 95% CI = 1.03-1.26, p = 0.014; GG versus GA+AA OR = 1.10, 95% CI = 1.02-1.19, p = 0.012; GG versus AA OR = 1.20, 95% CI = 1.07-1.34, p = 0.002; respectively). Results of subgroup analysis by ethnicity revealed positive correlations between the SERPING1 rs2511989 polymorphism and risk of AMD among Caucasians under five genetic models (all p<0.05), but not among Asians (all p>0.05).CONCLUSIONS:
The current meta-analysis shows that the SERPING1 rs2511989 polymorphism may have a positive effect on the risk of AMD, especially among Caucasians.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Inativadoras do Complemento 1
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Degeneração Macular
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article