Transition metal-mediated CâO and CâC bond-forming reactions: a regioselective strategy for the synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrazines.
J Org Chem
; 79(22): 11209-14, 2014 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-25369461
ABSTRACT
A novel and convenient transformation for the regiospecific synthesis of functionalized imidazo[1,2-a]pyridine aldehydes/ketones and 3-vinyl imidazo[1,2-a]pyridines has been developed via copper(I)- and palladium(II)-catalyzed cyclization. The one-pot reaction proceeds smoothly with commercially available catalysts and affords the products in moderate to good yields. It represents an efficient approach for the formation of C-N, CâO, and CâC bonds under mild conditions.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2014
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Article