Leukocyte ß-adrenergic receptor sensitivity and depression severity in patients with heart failure.
Psychosom Med
; 76(9): 726-31, 2014.
Article
em En
| MEDLINE
| ID: mdl-25373889
ABSTRACT
OBJECTIVES:
Clinical outcomes are worse for patients with heart failure (HF) and elevated depression symptoms. Depression-related sympathoimmune dysregulation may be one mechanism leading to poorer HF prognosis. Sympathetically mediated adrenergic activity is known to regulate immune activity via ß-adrenergic receptors (ß-ARs). However, studies show conflicting relationships between leukocyte ß-AR sensitivity and depression symptoms. The aim of this study was to determine in patients with HF the relationship of leukocyte ß-AR sensitivity with two diverse measures of depression, self-report questionnaire versus clinical diagnostic interview.METHODS:
Patients with HF (N = 73, mean [standard deviation] age = 56.3 [13.0]) completed the Beck Depression Inventory-1A and a modified Structured Clinical Interview for the DSM-IV. Leukocyte ß-AR sensitivity was determined from isoproterenol-stimulated cyclic adenosine monophosphate levels; plasma norepinephrine and epinephrine were also assessed.RESULTS:
Patients with major depression determined by Structured Clinical Interview for the DSM-IV had significantly higher ß-AR sensitivity than did nondepressed patients (F(6,72) = 9.27, p = .003, η = 0.12). The Beck Depression Inventory-1A revealed a more complex relationship. Minimal, mild, and moderate-to-severe depression symptom groups had significant differences in ß-AR sensitivity (F(7,72) = 7.03, p = .002, η = 0.18); mild symptoms were associated with reduced ß-AR sensitivity and moderate-to-severe symptoms with higher ß-AR sensitivity compared with patients with minimal depressive symptoms.CONCLUSIONS:
Clinical depression was associated with elevated ß-AR sensitivity in patients with HF. By deconstructing depression measurements, a greater depth of information may be garnered to potentially reveal subtypes of depression symptoms and their relation to ß-AR sensitivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Adrenérgicos beta
/
Depressão
/
Transtorno Depressivo Maior
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Insuficiência Cardíaca
/
Leucócitos
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article