The prophage-encoded hyaluronate lyase has broad substrate specificity and is regulated by the N-terminal domain.

Singh, Sudhir Kumar; Bharati, Akhilendra Pratap; Singh, Neha; Pandey, Praveen; Joshi, Pankaj; Singh, Kavita; Mitra, Kalyan; Gayen, Jiaur R; Sarkar, Jayanta; Akhtar, Md Sohail

Singh, Sudhir Kumar; Bharati, Akhilendra Pratap; Singh, Neha; Pandey, Praveen; Joshi, Pankaj; Singh, Kavita; Mitra, Kalyan; Gayen, Jiaur R; Sarkar, Jayanta; Akhtar, Md Sohail.

Afiliação

Singh SK; From the Molecular and Structural Biology Division.
Bharati AP; From the Molecular and Structural Biology Division.
Singh N; From the Molecular and Structural Biology Division.
Pandey P; Biochemistry Division.
Joshi P; Pharmacokinetics and Metabolism Division, and.
Singh K; Sophisticated Analytical Instrument Facility, Council of Scientific and Industrial Research-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, India, PIN 226 031 and.
Mitra K; Sophisticated Analytical Instrument Facility, Council of Scientific and Industrial Research-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, India, PIN 226 031 and Academy of Scientific and Innovative Research, Chennai, India, PIN 600 113.
Gayen JR; Pharmacokinetics and Metabolism Division, and Academy of Scientific and Innovative Research, Chennai, India, PIN 600 113.
Sarkar J; Biochemistry Division, Academy of Scientific and Innovative Research, Chennai, India, PIN 600 113.
Akhtar MS; From the Molecular and Structural Biology Division, Academy of Scientific and Innovative Research, Chennai, India, PIN 600 113 sohail@cdri.res.in.

J Biol Chem ; 289(51): 35225-36, 2014 Dec 19.

Article em En | MEDLINE | ID: mdl-25378402

Assuntos

Polissacarídeo-Liases/metabolismo; Prófagos/enzimologia; Streptococcus equi/virologia; Proteínas Virais/metabolismo; Motivos de Aminoácidos/genética; Animais; Domínio Catalítico; Sulfatos de Condroitina/metabolismo; Dermatan Sulfato/metabolismo; Eletroforese em Gel de Poliacrilamida; Polarização de Fluorescência; Glicosaminoglicanos/metabolismo; Células HCT116; Cavalos; Humanos; Receptores de Hialuronatos/metabolismo; Ácido Hialurônico/metabolismo; Cinética; Microscopia Confocal; Modelos Moleculares; Mutação; Polissacarídeo-Liases/química; Polissacarídeo-Liases/genética; Prófagos/genética; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Especificidade por Substrato; Proteínas Virais/química; Proteínas Virais/genética

Palavras-chave

Bacteriophage; Domain; Enzyme Catalysis; Glycosaminoglycan; Hyaluronate; Hyaluronic Acid; Streptococcus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeo-Liases / Proteínas Virais / Streptococcus equi / Prófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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