Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of &#916;F508-cystic fibrosis transmembrane conductance regulator (&#916;F508-CFTR).

Caohuy, Hung; Yang, Qingfeng; Eudy, Yvonne; Ha, Thien-An; Xu, Andrew E; Glover, Matthew; Frizzell, Raymond A; Jozwik, Catherine; Pollard, Harvey B

Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).

Caohuy, Hung; Yang, Qingfeng; Eudy, Yvonne; Ha, Thien-An; Xu, Andrew E; Glover, Matthew; Frizzell, Raymond A; Jozwik, Catherine; Pollard, Harvey B.

Afiliação

Caohuy H; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and hung.caohuy@usuhs.edu.
Yang Q; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and.
Eudy Y; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and.
Ha TA; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and.
Xu AE; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and.
Glover M; the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Frizzell RA; the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224.
Jozwik C; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and.
Pollard HB; From the Department of Anatomy, Physiology, and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 and harvey.pollard@usuhs.edu.

J Biol Chem ; 289(52): 35953-68, 2014 Dec 26.

Article em En | MEDLINE | ID: mdl-25384981

Assuntos

Ceramidas/farmacologia; Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo; Proteínas Imediatamente Precoces/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Linhagem Celular; Membrana Celular/metabolismo; Fibrose Cística/tratamento farmacológico; Regulador de Condutância Transmembrana em Fibrose Cística/genética; Avaliação Pré-Clínica de Medicamentos; Complexos Endossomais de Distribuição Requeridos para Transporte/metabolismo; Ativação Enzimática/efeitos dos fármacos; Humanos; Interleucina-8/metabolismo; Ubiquitina-Proteína Ligases Nedd4; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Processamento de Proteína Pós-Traducional; Estabilidade Proteica; Transporte Proteico; Piruvato Desidrogenase Quinase de Transferência de Acetil; Deleção de Sequência; Transdução de Sinais; Relação Estrutura-Atividade; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

Ceramide; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator (CFTR); Inflammation; Membrane Trafficking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceramidas / Proteínas Serina-Treonina Quinases / Proteínas Imediatamente Precoces / Regulador de Condutância Transmembrana em Fibrose Cística Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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