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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.
Izzo, Nicholas J; Staniszewski, Agnes; To, Lillian; Fa, Mauro; Teich, Andrew F; Saeed, Faisal; Wostein, Harrison; Walko, Thomas; Vaswani, Anisha; Wardius, Meghan; Syed, Zanobia; Ravenscroft, Jessica; Mozzoni, Kelsie; Silky, Colleen; Rehak, Courtney; Yurko, Raymond; Finn, Patricia; Look, Gary; Rishton, Gilbert; Safferstein, Hank; Miller, Miles; Johanson, Conrad; Stopa, Edward; Windisch, Manfred; Hutter-Paier, Birgit; Shamloo, Mehrdad; Arancio, Ottavio; LeVine, Harry; Catalano, Susan M.
Afiliação
  • Izzo NJ; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Staniszewski A; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
  • To L; Stanford University Medical School Behavioral and Functional Neuroscience Laboratory, Palo Alto, California, United States of America.
  • Fa M; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
  • Teich AF; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
  • Saeed F; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
  • Wostein H; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Walko T; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Vaswani A; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Wardius M; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Syed Z; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Ravenscroft J; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Mozzoni K; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Silky C; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Rehak C; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Yurko R; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Finn P; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Look G; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Rishton G; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Safferstein H; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
  • Miller M; Department of Pathology and Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
  • Johanson C; Department of Pathology and Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
  • Stopa E; Department of Pathology and Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.
  • Windisch M; NeuroScios, GmbH, Graz, Austria.
  • Hutter-Paier B; QPS Austria GmbH, Grambach, Austria.
  • Shamloo M; Stanford University Medical School Behavioral and Functional Neuroscience Laboratory, Palo Alto, California, United States of America.
  • Arancio O; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America.
  • LeVine H; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America.
  • Catalano SM; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, United States of America.
PLoS One ; 9(11): e111898, 2014.
Article em En | MEDLINE | ID: mdl-25390368

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Sinapses / Peptídeos beta-Amiloides / Doença de Alzheimer / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Sinapses / Peptídeos beta-Amiloides / Doença de Alzheimer / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article