The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
Mov Disord
; 30(2): 278-83, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25393808
ABSTRACT
BACKGROUND:
Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).METHODS:
The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.RESULTS:
Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation 13.9 point difference, P = 0.03; two-mutation 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13).CONCLUSIONS:
First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Predisposição Genética para Doença
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Ubiquitina-Proteína Ligases
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Mutação
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Transtorno Obsessivo-Compulsivo
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article