Your browser doesn't support javascript.
loading
Effect of enalapril at rest and during isometric and dynamic exercise in essential hypertensive patients.
Fariello, R; Boni, E; Alicandri, C; Zaninelli, A; Cantalamessa, A; Corda, L; Muiesan, G.
Afiliação
  • Fariello R; Department of Internal Medicine, University of Brescia, Italy.
J Int Med Res ; 17(1): 76-81, 1989.
Article em En | MEDLINE | ID: mdl-2540050
Vasodilator drugs reduce peripheral vascular resistance but lead to a secondary baroreflex-mediated chronotropic effect. After angiotensin-converting enzyme inhibition, blood pressure falls without associated tachycardia. In a previous study it was observed that enalapril increased vagal tone in essential hypertensive patients. In order to evaluate the effect of enalapril on sympathetic stimulation 10 mild to moderate hypertensive patients were studied during static (hand grip) and dynamic exercise (bicycle ergometer), after 2 weeks of placebo and after 1 month of treatment with 20-40 mg enalapril once daily. Enalapril significantly reduced blood pressure and the rate-pressure product at rest and at peak dynamic exercise. There was no effect on supine and maximal heart rate. Enalapril also significantly reduced blood pressure during hand grip, but did not interfere with the rate of the increase. Thus, enalapril does not seem to interfere with sympathetic adaptation to stress.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enalapril / Esforço Físico / Hipertensão Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1989 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enalapril / Esforço Físico / Hipertensão Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1989 Tipo de documento: Article