Maternal thrombophilia and adverse pregnancy outcome: a case-control study.
Acta Haematol
; 133(2): 242-8, 2015.
Article
em En
| MEDLINE
| ID: mdl-25401392
ABSTRACT
OBJECTIVE:
To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors. PATIENTS ANDMETHODS:
A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors.RESULTS:
Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls.CONCLUSION:
Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
/
Resultado da Gravidez
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Aborto Espontâneo
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Trombofilia
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
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Pregnancy
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article