Duodenal adenomas in familial adenomatous polyposis: their structure and cellular composition with particular reference to endocrine hyperplasia.
Virchows Arch A Pathol Anat Histopathol
; 414(4): 315-9, 1989.
Article
em En
| MEDLINE
| ID: mdl-2540589
ABSTRACT
134 duodenal biopsies from 14 patients with familial adenomatous polyposis were evaluated by light microscopy for the presence of adenoma. Staining reactions for endocrine cells were applied. 90 biopsies contained adenoma, almost all of the tubular type (98%) with dysplasia, ranging from mild to moderate. Accompanying hyperplasia of argyrophil and argentaffin endocrine cells was found in 91% and 64% of the adenomas, respectively. Based on histological criteria it is concluded that the risk of carcinoma development in the duodenum could equal that in colon and rectum. The observation of endocrine hyperplasia is new, and further investigations are needed before the significance of this finding can be evaluated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenoma
/
Polipose Adenomatosa do Colo
/
Neoplasias Duodenais
/
Glândulas Endócrinas
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article