Initial study on in vivo conductivity mapping of breast cancer using MRI.
J Magn Reson Imaging
; 42(2): 371-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25413153
ABSTRACT
PURPOSE:
To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. MATERIALS ANDMETHODS:
A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2 -weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity.RESULTS:
By employing the coil combination, the relative error in the conductivity map was reduced from ~70% to 10%. The average conductivity values in breast cancers regions (0.89 ± 0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005).CONCLUSION:
This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pletismografia de Impedância
/
Algoritmos
/
Neoplasias da Mama
/
Imageamento por Ressonância Magnética
/
Interpretação de Imagem Assistida por Computador
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article