Intravoxel incoherent motion MRI for liver fibrosis assessment: a pilot study.
Acta Radiol
; 56(12): 1428-36, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25414372
ABSTRACT
BACKGROUND:
There has been a growing need for an imaging method for the accurate diagnosis and staging of liver fibrosis as a non-invasive alternative to liver biopsy.PURPOSE:
To evaluate the feasibility of intra-voxel incoherent motion (IVIM) imaging for classifying the severity of liver fibrosis. MATERIAL ANDMETHODS:
Fifty-seven patients who underwent navigator-triggered, diffusion-weighted imaging (DWI) of the liver on a 1.5-T system using nine b-values and had a reliable reference standard for the diagnosis of liver fibrosis (histopathologic findings [n = 27] or clinical findings for normal [n = 18] or cirrhotic liver [n = 12]), were included in our study. Liver apparent diffusion coefficient (ADC), pure diffusion (Dslow), perfusion fraction (f), and perfusion-related diffusion (Dfast), and the product f · Dfast were compared with the liver fibrosis stages (F). The accuracies of these parameters in diagnosing severe liver fibrosis (F ≥3) were evaluated using the receiver-operating characteristic (ROC) curve analysis.RESULTS:
The liver fibrosis stages had the strongest negative correlation with f · Dfast (ρ = -0.52). All of the parameters, except for Dslow, were significantly lower in patients with F ≥3 than in those with F ≤2 (P ≤ 0.001). The area under the ROC curve for diagnosing severe fibrosis was the largest for f · Dfast (0.844) with an overall accuracy of 79.0% (45/57) at the optimal cutoff value and followed by f (0.834), Dfast (0.773), ADC (0.762), and Dslow (0.656).CONCLUSION:
IVIM imaging is a promising method for classifying the severity of liver fibrosis, with the product f · Dfast being the most accurate parameter.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
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Imagem de Difusão por Ressonância Magnética
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Cirrose Hepática
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article