Active site targeting of hedgehog precursor protein with phenylarsine oxide.
Chembiochem
; 16(1): 55-8, 2015 Jan 02.
Article
em En
| MEDLINE
| ID: mdl-25418613
ABSTRACT
Hedgehog proteins, signaling molecules implicated in human embryo development and cancer, can be inhibited at the stage of autoprocessing by the trivalent arsenical phenyl arsine oxide (PhAs(III) ). The interaction (apparent Ki , 4 × 10(-7) M) is characterized by an optical binding assay and by NMR spectroscopy. PhAs(III) appears to be the first validated inhibitor of hedgehog autoprocessing, which is unique to hedgehog proteins and essential for biological activity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsenicais
/
Precursores de Proteínas
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Proteínas Recombinantes de Fusão
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Colesterol
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Proteínas Hedgehog
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article