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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Wetzel-Smith, Monica K; Hunkapiller, Julie; Bhangale, Tushar R; Srinivasan, Karpagam; Maloney, Janice A; Atwal, Jasvinder K; Sa, Susan M; Yaylaoglu, Murat B; Foreman, Oded; Ortmann, Ward; Rathore, Nisha; Hansen, David V; Tessier-Lavigne, Marc; Mayeux, Richard; Pericak-Vance, Margaret; Haines, Jonathan; Farrer, Lindsay A; Schellenberg, Gerard D; Goate, Alison; Behrens, Timothy W; Cruchaga, Carlos; Watts, Ryan J; Graham, Robert R.
Afiliação
  • Wetzel-Smith MK; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Hunkapiller J; Department of Human Genetics, Genentech, South San Francisco, California, USA.
  • Bhangale TR; Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California, USA.
  • Srinivasan K; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Maloney JA; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Atwal JK; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Sa SM; Department of Pathology, Genentech, South San Francisco, California, USA.
  • Yaylaoglu MB; Department of Pathology, Genentech, South San Francisco, California, USA.
  • Foreman O; Department of Pathology, Genentech, South San Francisco, California, USA.
  • Ortmann W; Department of Human Genetics, Genentech, South San Francisco, California, USA.
  • Rathore N; Department of Human Genetics, Genentech, South San Francisco, California, USA.
  • Hansen DV; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Tessier-Lavigne M; Laboratory of Brain Development and Repair, Rockefeller University, New York, New York, USA.
  • Mayeux R; 1] Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
  • Pericak-Vance M; 1] The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA. [2] Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, USA.
  • Haines J; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
  • Farrer LA; 1] Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA. [2] Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA. [3] Department of Ophthalmology, Boston University S
  • Schellenberg GD; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
  • Goate A; 1] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA. [3] Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri,
  • Behrens TW; Department of Human Genetics, Genentech, South San Francisco, California, USA.
  • Cruchaga C; 1] Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Watts RJ; Department of Neuroscience, Genentech, South San Francisco, California, USA.
  • Graham RR; Department of Human Genetics, Genentech, South San Francisco, California, USA.
Nat Med ; 20(12): 1452-7, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25419706
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Fator de Crescimento Neural / Receptores de Superfície Celular / Doença de Alzheimer / Neurônios Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Fator de Crescimento Neural / Receptores de Superfície Celular / Doença de Alzheimer / Neurônios Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article