Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1&#945; by inhibiting prolyl-4-hydroxylase PHD2.

Hou, Peifeng; Kuo, Ching-Ying; Cheng, Chun-Ting; Liou, Jing-Ping; Ann, David K; Chen, Qiang

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

Hou, Peifeng; Kuo, Ching-Ying; Cheng, Chun-Ting; Liou, Jing-Ping; Ann, David K; Chen, Qiang.

Afiliação

Hou P; Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America; Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
Kuo CY; Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America.
Cheng CT; Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America.
Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Ann DK; Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America.
Chen Q; Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.

PLoS One ; 9(11): e113865, 2014.

Article em En | MEDLINE | ID: mdl-25420025

Assuntos

Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Prolina Dioxigenases do Fator Induzível por Hipóxia/antagonistas & inibidores; Prolina Dioxigenases do Fator Induzível por Hipóxia/metabolismo; Ácidos Cetoglutáricos/farmacologia; Aminoácidos Dicarboxílicos/farmacologia; Western Blotting; Linhagem Celular; Linhagem Celular Tumoral; Desferroxamina/farmacologia; Expressão Gênica/genética; Células HEK293; Humanos; Hidroxilação/efeitos dos fármacos; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Prolina Dioxigenases do Fator Induzível por Hipóxia/genética; Quelantes de Ferro/farmacologia; Células MCF-7; Prolina/metabolismo; Proteólise/efeitos dos fármacos; Interferência de RNA; Reação em Cadeia da Polimerase Via Transcriptase Reversa

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Subunidade alfa do Fator 1 Induzível por Hipóxia / Prolina Dioxigenases do Fator Induzível por Hipóxia / Ácidos Cetoglutáricos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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