Clinical significance of cyclophilin a expression in esophageal squamous cell carcinoma.

OBJECTIVE: To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance. METHOD: Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed. RESULTS: There were 166 patients with high expression of CypA (70.23%) and a higher expression in 69.3% of males and 73.3% in females. The CypA expression was irrelevant to age, tumor location, lymph node metastasis, and tumor differentiation degree. The Kaplan-Meier survival curve analysis showed that the expression of CypA was associated with the prognosis of patients with esophageal squamous cell carcinoma. CONCLUSION: The poor prognosis of esophageal cancer patients was associated with high expression of CypA.