Age-specific changes in left ventricular diastolic function: a velocity-encoded magnetic resonance imaging study.
Eur Radiol
; 25(4): 1077-86, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25430004
ABSTRACT
OBJECTIVES:
Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations.METHODS:
We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E') peak velocity.RESULTS:
MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E' (r = -0.63, p < 0.0001) and flow-rate parameters were strongly and independently associated to age (Ef/Afr = -0.63, DTr = 0.46, IVRTr = 0.44, Ef/FVr = -0.55, Af/FVr = 0.56, p < 0.0001). Furthermore, LV relaxation parameters (E', DT, IVRT), were independently associated to LV remodelling (LV mass/end-diastolic volume) and myocardial wall thickness (p < 0.01).CONCLUSIONS:
PC-MRI age-related reference ranges of diastolic parameters are provided. Such parameters might be useful for a fast, reproducible and reliable characterization of diastolic function in patients referred for clinical MRI exam KEY POINTS ⢠MRI age-related reference values of left ventricular diastolic parameters are provided. ⢠MRI diastolic parameters can characterise sub-clinical age-related variations in healthy individuals. ⢠Diastolic function would complement cardiac MRI exam with currently neglected data. ⢠Diastolic function would enhance MRI diagnostic value in cardiomyopathy and heartfailure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Função Ventricular Esquerda
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Imagem Cinética por Ressonância Magnética
/
Ventrículos do Coração
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article