Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.
Eur J Immunol
; 45(2): 513-24, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25430631
ABSTRACT
Toll-like receptors (TLRs) can recognize microbial patterns and utilize adaptor molecules, such as-MyD88 or (TRIF TIR-domain-containing adapter-inducing interferon-ß), to initiate downstream signaling that ultimately affects the initiation of adaptive immunity. In addition to this inflammatory role, TLR5 expression on dendritic cells can favor antigen presentation of flagellin peptides and thus increase the sensitivity of flagellin-specific T-cell responses in vitro and in vivo. Here, we examined the role of alternative signaling pathways that might regulate flagellin antigen presentation in addition to MyD88. These studies suggest a requirement for spleen tyrosine kinase, a noncanonical TLR-signaling adaptor molecule, and its downstream molecule CARD9 in regulating the sensitivity of flagellin-specific CD4(+) T-cell responses in vitro and in vivo. Thus, a previously unappreciated signaling pathway plays an important role in regulating the dominance of flagellin-specific T-cell responses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Proteínas Tirosina Quinases
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Linfócitos T CD4-Positivos
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Transdução de Sinais
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Peptídeos e Proteínas de Sinalização Intracelular
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Proteínas Adaptadoras de Sinalização CARD
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Flagelina
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article