Your browser doesn't support javascript.
loading
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
García-Martínez, Elena; Gil, Ginés Luengo; Benito, Asunción Chaves; González-Billalabeitia, Enrique; Conesa, María Angeles Vicente; García García, Teresa; García-Garre, Elisa; Vicente, Vicente; Ayala de la Peña, Francisco.
Afiliação
  • García-Martínez E; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. helenagarciam@gmail.com.
  • Gil GL; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. gines.luengo@um.es.
  • Benito AC; Department of Pathology, University Hospital Morales Meseguer, Murcia, Spain. mariaa.chaves@carm.es.
  • González-Billalabeitia E; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. engonbil@um.es.
  • Conesa MA; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. marianvico@yahoo.es.
  • García García T; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. tggarc@gmail.com.
  • García-Garre E; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. eliggarre3@gmail.com.
  • Vicente V; Department of Hematology and Medical Oncology, University Hospital Morales Meseguer, Murcia, Spain. vvg@um.es.
  • Ayala de la Peña F; Centro Regional de Hemodonación, Murcia, Spain. vvg@um.es.
Breast Cancer Res ; 16(6): 488, 2014 Nov 29.
Article em En | MEDLINE | ID: mdl-25432519
INTRODUCTION: Tumor microenvironment immunity is associated with breast cancer outcome. A high lymphocytic infiltration has been associated with response to neoadjuvant chemotherapy, but the contribution to response and prognosis of immune cell subpopulations profiles in both pre-treated and post-treatment residual tumor is still unclear. METHODS: We analyzed pre- and post-treatment tumor-infiltrating immune cells (CD3, CD4, CD8, CD20, CD68, Foxp3) by immunohistochemistry in a series of 121 breast cancer patients homogeneously treated with neoadjuvant chemotherapy. Immune cell profiles were analyzed and correlated with response and survival. RESULTS: We identified three tumor-infiltrating immune cell profiles, which were able to predict pathological complete response (pCR) to neoadjuvant chemotherapy (cluster B: 58%, versus clusters A and C: 7%). A higher infiltration by CD4 lymphocytes was the main factor explaining the occurrence of pCR, and this association was validated in six public genomic datasets. A higher chemotherapy effect on lymphocytic infiltration, including an inversion of CD4/CD8 ratio, was associated with pCR and with better prognosis. Analysis of the immune infiltrate in post-chemotherapy residual tumor identified a profile (cluster Y), mainly characterized by high CD3 and CD68 infiltration, with a worse disease free survival. CONCLUSIONS: Breast cancer immune cell subpopulation profiles, determined by immunohistochemistry-based computerized analysis, identify groups of patients characterized by high response (in the pre-treatment setting) and poor prognosis (in the post-treatment setting). Further understanding of the mechanisms underlying the distribution of immune cells and their changes after chemotherapy may contribute to the development of new immune-targeted therapies for breast cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Linfócitos do Interstício Tumoral / Carcinoma Ductal de Mama / Microambiente Tumoral Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Linfócitos do Interstício Tumoral / Carcinoma Ductal de Mama / Microambiente Tumoral Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article