An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region.
J Infect Chemother
; 21(4): 302-4, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25442807
ABSTRACT
The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
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Vírus da Hepatite B
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Deleção de Sequência
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Carcinoma Hepatocelular
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Hepatite B
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Antígenos de Superfície da Hepatite B
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Neoplasias Hepáticas
Tipo de estudo:
Risk_factors_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article