[Purulent pericarditis and colonic infiltrating to Salmonella enteritidis complicated by acute intussusception in a case of IL-12Rß1 deficiency]. / Péricardite purulente et infiltration colique à Salmonella enteritidis compliquée d'invagination intestinale aiguë dans un cas de déficit en IL-12Rß1.

ABSTRACT

IL-12 receptor ß1 deficiency (IL-12Rß1) predisposes patients to mycobacteria and Salmonella infections. We report a case of IL-12Rß1 deficiency with a fatal multi-resistant Salmonella enteritidis infection. This boy was born after from a consanguineous marriage, and diagnosed as having a IL-12Rß1 deficiency since the age of 3 months. He presented with recurrent Salmonella enteritidis essentially digestive localization, complicated by purulent pericarditis at the same germ at the age of two and a half years. At the age of 3, a colonic infiltration due to a Salmonella enteritidis resistant to antibiotics, was complicated by acute intussusception, and the child died. The IL-12Rß1 deficiency is considered as having a good prognosis, in contrast to what happened in our patient. We review therapeutic issues in these patients.