Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.
Toxicol In Vitro
; 29(1): 259-70, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25448812
ABSTRACT
The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitization potency prediction. The results of the first phase systematic evaluation of 16 test methods are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data,potential for throughput, transferability and accessibility in cooperation with the test method developers.A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy combined with bioavailability and skin metabolism data and exposure consideration is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dermatite Alérgica de Contato
/
Alternativas aos Testes com Animais
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article