Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer.
Cancer Lett
; 356(2 Pt B): 819-27, 2015 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-25449777
ABSTRACT
We previously reported that activin produces a signal with a tumor suppressive role in pancreatic cancer (PC). Here, the association between plasma activin A and survival in patients with advanced PC was investigated. Contrary to our expectations, however, patients with high plasma activin A levels had a significantly shorter survival period than those with low levels (median survival, 314 days vs. 482 days, P = 0.034). The cellular growth of the MIA PaCa-2 cell line was greatly enhanced by activin A via non-SMAD pathways. The cellular growth and colony formation of an INHBA (beta subunit of inhibin)-overexpressed cell line were also enhanced. In a xenograft study, INHBA-overexpressed cells tended to result in a larger tumor volume, compared with a control. The bodyweights of mice inoculated with INHBA-overexpressed cells decreased dramatically, and these mice all died at an early stage, suggesting the occurrence of activin-induced cachexia. Our findings indicated that the activin signal can promote cancer progression in a subset of PC and might be involved in cachexia. The activin signal might be a novel target for the treatment of PC.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Caquexia
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Biomarcadores Tumorais
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Ativinas
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Aged80
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article