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A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay.
Sameshima, Tomoya; Miyahisa, Ikuo; Homma, Misaki; Aikawa, Katsuji; Hixon, Mark S; Matsui, Junji.
Afiliação
  • Sameshima T; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Miyahisa I; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan; Enzymology and Biophysical Chemistry, Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Homma M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Aikawa K; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Hixon MS; Enzymology and Biophysical Chemistry, Takeda California, Inc., 10410 Science Center Drive, San Diego, CA 92121, United States.
  • Matsui J; Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Bioorg Med Chem Lett ; 24(24): 5836-5839, 2014 Dec 15.
Article em En | MEDLINE | ID: mdl-25452002
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína bcl-X / Proteína de Sequência 1 de Leucemia de Células Mieloides / Cetoácidos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína bcl-X / Proteína de Sequência 1 de Leucemia de Células Mieloides / Cetoácidos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article